The role of atorvastatin in collateral circulation formation induced by encephaloduroarteriosynangiosis: a prospective trial

OBJECTIVE This prospective study was designed to confirm the role of atorvastatin in collateral circulation formation induced by encephaloduroarteriosynangiosis (EDAS) patients with moyamoya disease (MMD). METHODS Patients who were diagnosed MMD at Department Neurosurgery Fifth Medical Center Chinese PLA General Hospital, Beijing, China, between June 2017 and May 2018 included. Blood samples obtained from an antecubital vein analyzed using flow cytometry. Endothelial progenitor cells (EPCs) defined as CD34 br CD133 + CD45 dim KDR . All included underwent EDAS. voluntarily chose whether undergo treatment after The correlation good postoperative evaluated. RESULTS A total 106 this study. Fifty-three (50%) received treatment. baseline characteristics did not display statistically significant differences atorvastatin-treated non-atorvastatin groups. Seventy-eight (42.9%) 182 hemispheres investigated postoperatively classified grade circulation, 47 (25.8%) B, 57 (31.3%) C. Multivariate analysis revealed that only significantly correlated EDAS (p = 0.041). CONCLUSIONS results clinical trial have indicated administered 20 mg daily is safe effective for